Pokémon Mystery Dungeon: Rescue Team DX is set in a world inhabited only by Pokémon. When players first open their eyes, they see a Pokémon in front of them, and they can understand what it’s saying. Upon closer inspection, players will realize that they themselves have become a Pokémon.

According to the Pokémon they meet, natural disasters have suddenly started occurring all over this world, causing all kinds of problems. Players and their partner Pokémon decide to form a rescue team to go help Pokémon that are in trouble.